kerafast總代理靶(ba)點科技貨號EB0011單克(ke)隆(long)抗體Anti-VSV-M [23H12] Antibody與VSV-M蛋白反應。

產品特色：

-與VSV-M蛋白發生反應

-適用于蛋白(bai)質印跡應用

背(bei)景介紹：

水皰(pao)性口炎(yan)病(bing)毒(du)(du)（VSV）是一種經過充分(fen)研究(jiu)的包膜負鏈RNA病(bing)毒(du)(du)。VSV 基因組編碼(ma) 5 種蛋白質：N、P、M、G 和 L。G蛋白（糖(tang)蛋白）位(wei)于(yu)病(bing)毒(du)(du)粒子表面(mian)，負責(ze)病(bing)毒(du)(du)附(fu)著和滲透(tou)。此外，許(xu)多慢靜脈載體是用來自印第(di)安(an)納州血清(qing)型的VSV-G假分(fen)型的。

水皰性口(kou)炎病(bing)(bing)毒(du)（VSV）是一種(zhong)(zhong)經(jing)過充(chong)分(fen)研究的(de)(de)包膜(mo)負鏈RNA病(bing)(bing)毒(du)。VSV 基(ji)因組編碼 5 種(zhong)(zhong)蛋(dan)白(bai)質：N、P、M、G 和 L。M蛋(dan)白(bai)（或基(ji)質蛋(dan)白(bai)）負責結合核衣(yi)殼并(bing)將其凝聚成緊密盤繞的(de)(de)螺旋，并(bing)將核衣(yi)殼與包膜(mo)結合。M蛋(dan)白(bai)的(de)(de)這種(zhong)(zhong)活性使病(bing)(bing)毒(du)具有彈(dan)狀(zhuang)的(de)(de)形狀(zhuang)。除了M蛋(dan)白(bai)在病(bing)(bing)毒(du)組裝中的(de)(de)作用外，它還負責介導VSV發病(bing)(bing)機制的(de)(de)分(fen)子機制。野(ye)生(sheng)M型蛋(dan)白(bai)抑制感染細胞(bao)中的(de)(de)宿主(zhu)基(ji)因表達并(bing)抑制抗病(bing)(bing)毒(du)反應。

Background：

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The G protein (glycoprotein) is located at the virion surface and is responsible for virus attachment and penetration. Additionally, many lentivrial vectors are pseudotyped with VSV-G from the Indiana serotype.

Vesicular stomatitis virus (VSV) is a well studied, enveloped, negative-strand RNA virus. The VSV genome encodes for 5 proteins: N, P, M, G, and L. The M protein (or matrix protein) is responsible for binding the nucleocapsid and condenses it into a tightly coiled helix and binds the nucleocapsid to the envelope. This activity of the M protein is what gives the virus its bullet like shape. In addition to M protein's role in virus assembly, it is also responsible for mediating molecular mechanisms of VSV pathogenesis. Wild-type M protein surpresses host gene expression in infected cells and inhibits antiviral responses.

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